Journal article
Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
- Abstract:
-
Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-r...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1113921108
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 108
- Issue:
- 52
- Pages:
- 21028-21033
- Publication date:
- 2011-12-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
221409
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:221409
- UUID:
-
uuid:64e5ef19-c907-4755-b698-223aeba1ff37
- Local pid:
- pubs:221409
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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