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Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

Abstract:

Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-r...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1113921108

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
52
Pages:
21028-21033
Publication date:
2011-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:64e5ef19-c907-4755-b698-223aeba1ff37
Source identifiers:
221409
Local pid:
pubs:221409

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