Journal article icon

Journal article

Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.

Abstract:

Replication-defective adenovirus vectors based on human serotype 5 (Ad5) induce protective immune responses against diverse pathogens and cancer in animal models, as well as elicit robust and sustained cellular immunity in humans. However, most humans have neutralizing antibodies to Ad5, which can impair the immunological potency of such vaccines. Here, we show that rare serotypes of human adenoviruses, which should not be neutralized in most humans, are far less potent as vaccine vectors tha...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Expand authors...
Journal:
Science translational medicine
Volume:
4
Issue:
115
Pages:
115ra2
Publication date:
2012-01-01
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Source identifiers:
222386

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP