In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line.

Journal article

Depending upon local conditions, brushite (CaHPO4 x 2 H2O) cements may be largely resorbed or (following hydrolysis to hydroxyapatite) remain stable in vivo. To determine which factors influence cement resorption, previous studies have investigated the solution-driven degradation of brushite cements in vitro in the absence of any cells. However, the mechanism of cell-mediated biodegradation of the brushite cement is still unknown. The aim of the current study was to observe the cell-mediated ...

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Authors: Xia, Z; Grover, L; Huang, Y; Adamopoulos, I; Gbureck, U

• Publication status: Published
• Journal: Biomaterials
• Volume: 27
• Issue: 26
• Pages: 4557-4565
• Publication date: 2006-09-01
• DOI: 10.1016/j.biomaterials.2006.04.030
• EISSN: 1878-5905
• ISSN: 0142-9612
• Language: English
• Keywords: Cell Line; Animals; Biodegradation, Environmental; Microscopy, Electron, Scanning; Mice; Models, Biological; Biocompatible Materials; Microscopy; Bone Cements; Calcium Phosphates; Macrophages