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D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.

Abstract:

The heroin analogue 1-methyl-4-phenylpyridinium, MPP(+), both in vitro and in vivo, produces death of dopaminergic substantia nigral cells by inhibiting the mitochondrial NADH dehydrogenase multienzyme complex, producing a syndrome indistinguishable from Parkinson's disease. Similarly, a fragment of amyloid protein, Abeta(1-42), is lethal to hippocampal cells, producing recent memory deficits characteristic of Alzheimer's disease. Here we show that addition of 4 mM d-beta-hydroxybutyrate prot...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.97.10.5440

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
10
Pages:
5440-5444
Publication date:
2000-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:64bbb7b7-3bc1-4e54-a934-05ae647d4438
Source identifiers:
106590
Local pid:
pubs:106590

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