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Haemoglobin and flow-mediated vasodilation.

Abstract:

A low [Hb] (Hb concentration) is out-balanced by peripheral vasodilation via mechanisms that are incompletely understood. Peripheral vasodilation is influenced by NO (nitric oxide) released from vascular endothelium in response to increased vessel wall shear stress, and absorption by Hb is the main mechanism by which the bioactivity of NO is disarmed. Thus we propose that graded NO absorption is the mechanism through which a low [Hb] is related to peripheral vasodilation. In the present study...

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Publication status:
Published

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Publisher copy:
10.1042/cs20050291

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Clinical science (London, England : 1979)
Volume:
110
Issue:
4
Pages:
467-473
Publication date:
2006-04-01
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
Source identifiers:
105334

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