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Haemoglobin and flow-mediated vasodilation.

Abstract:

A low [Hb] (Hb concentration) is out-balanced by peripheral vasodilation via mechanisms that are incompletely understood. Peripheral vasodilation is influenced by NO (nitric oxide) released from vascular endothelium in response to increased vessel wall shear stress, and absorption by Hb is the main mechanism by which the bioactivity of NO is disarmed. Thus we propose that graded NO absorption is the mechanism through which a low [Hb] is related to peripheral vasodilation. In the present study...

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Publication status:
Published

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Publisher copy:
10.1042/cs20050291

Authors


Madsen, PL More by this author
Scheuermann Freestone, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Channon, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Clinical science (London, England : 1979)
Volume:
110
Issue:
4
Pages:
467-473
Publication date:
2006-04-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:64bbb23c-0b63-4695-9e09-49991407d679
Source identifiers:
105334
Local pid:
pubs:105334

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