Predicting protein cellular localization using a domain projection method.

Journal article

We investigate the co-occurrence of domain families in eukaryotic proteins to predict protein cellular localization. Approximately half (300) of SMART domains form a "small-world network", linked by no more than seven degrees of separation. Projection of the domains onto two-dimensional space reveals three clusters that correspond to cellular compartments containing secreted, cytoplasmic, and nuclear proteins. The projection method takes into account the existence of "bridging" domains, that ...

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Authors: Mott, R; Schultz, J; Bork, P; Ponting, C

• Publication status: Published
• Journal: Genome research
• Volume: 12
• Issue: 8
• Pages: 1168-1174
• Publication date: 2002-08-01
• DOI: 10.1101/gr.96802
• EISSN: 1549-5469
• ISSN: 1088-9051
• Language: English
• Keywords: Membrane Proteins; Nuclear Proteins; Databases, Protein; Computational Biology; Animals; Benchmarking; Protein Sorting Signals; Software; Cytoplasm; Protein Structure, Tertiary; Probability; Proteins; Humans; Internet; Cell Compartmentation; Cluster Analysis