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Glycoviruses: chemical glycosylation retargets adenoviral gene transfer.

Abstract:
A sugar-specific transfection mechanism is introduced by the glycosylation of adenoviruses (AVs, see picture), and manipulation of the glycosylation pattern allows the selective transfection of human macrophages in favor of the usual target. This dramatic retargeting holds promise for the fine-tuning of adenoviruses for applications such as gene therapy. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.200461832

Authors


Pearce, OM More by this author
Fisher, KD More by this author
Humphries, J More by this author
Seymour, LW More by this author
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
44
Issue:
7
Pages:
1057-1061
Publication date:
2005-02-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:64aca517-1cb3-4e57-8b08-e195baafa719
Source identifiers:
32980
Local pid:
pubs:32980

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