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Journal article

Microcrystalline tyrosine (MCT®): A depot adjuvant in licensed allergy immunotherapy offers new opportunities in malaria.

Abstract:

Microcrystalline Tyrosine (MCT®) is a widely used proprietary depot excipient in specific immunotherapy for allergy. In the current study we assessed the potential of MCT to serve as an adjuvant in the development of a vaccine against malaria. To this end, we formulated the circumsporozoite protein (CSP) of P. vivax in MCT and compared the induced immune responses to CSP formulated in PBS or Alum. Both MCT and Alum strongly increased immunogenicity of CSP compared to PBS in both C57BL/6 and B...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/vaccines5040032

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
ORCID:
0000-0003-3510-9148
More by this author
Role:
Author
ORCID:
0000-0001-5853-8565
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Swiss National Science Foundation More from this funder
Allergy Therapeutics Company More from this funder
Brazilian National Council for Scientific and Technological Development More from this funder
Jenner Institute More from this funder
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Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Volume:
5
Issue:
4
Pages:
32-32
Publication date:
2017-09-05
Acceptance date:
2017-09-20
DOI:
EISSN:
2076-393X
ISSN:
2076-393X
Pubs id:
pubs:732054
URN:
uri:64ac201d-8c6a-4f9f-84fe-bd60c99acdec
UUID:
uuid:64ac201d-8c6a-4f9f-84fe-bd60c99acdec
Local pid:
pubs:732054
Language:
English
Keywords:

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