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Journal article

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points.

Abstract:

Haematopoiesis is the complex developmental process that maintains the turnover of all blood cell lineages. It critically depends on the correct functioning of rare, quiescent haematopoietic stem cells (HSCs) and more numerous, HSC-derived, highly proliferative and differentiating haematopoietic progenitor cells (HPCs). Infection is known to affect HSCs, with severe and chronic inflammatory stimuli leading to stem cell pool depletion, while acute, non-lethal infections exert transient and eve...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsob.160038

Authors


Vainieri, ML More by this author
Blagborough, AM More by this author
MacLean, AL More by this author
Haltalli, ML More by this author
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More from this funder
Funding agency for:
Fletcher, HA
Biotechnology and Biological Sciences Research Council More from this funder
European Research Council More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Issue:
6
Publication date:
2016-06-22
Acceptance date:
2016-05-27
DOI:
ISSN:
2046-2441
Pubs id:
pubs:631089
URN:
uri:64a51c0b-6aed-4f7f-a6c5-5d436d2e01cf
UUID:
uuid:64a51c0b-6aed-4f7f-a6c5-5d436d2e01cf
Local pid:
pubs:631089

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