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Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination.

Abstract:

New evidence indicates that termination of transcription is an important regulatory step, closely related to transcriptional interference and even transcriptional initiation. However, how this occurs is poorly understood. Recently, in vivo analysis of transcriptional termination for the human beta-globin gene revealed a new phenomenon--co-transcriptional cleavage (CoTC). This primary cleavage event within beta-globin pre-messenger RNA, downstream of the poly(A) site, is critical for efficient...

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Publication status:
Published

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Publisher copy:
10.1038/nature03032

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Nature
Volume:
432
Issue:
7016
Pages:
526-530
Publication date:
2004-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:649e27ca-2c80-468d-9329-984e92fb5a49
Source identifiers:
18200
Local pid:
pubs:18200

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