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Journal article

Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Abstract:
Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA interference (RNAi)-based targeted gene silencing is a quick, cost-effective, and easy-to-perform method to address questions regarding the function of genes, especially when hypomorphic knockdowns are needed. Therefore, effective transfectio... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13287-019-1144-x

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
St Hilda's College
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Stem Cell Research and Therapy Journal website
Volume:
43
Issue:
10
Publication date:
2019-01-24
Acceptance date:
2019-01-10
DOI:
EISSN:
1757-6512
Source identifiers:
966627
Language:
English
Keywords:
Pubs id:
pubs:966627
UUID:
uuid:6494deba-b92d-4b64-8c2b-9e62e20d9c03
Local pid:
pubs:966627
Deposit date:
2019-01-28

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