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Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Abstract:
Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA interference (RNAi)-based targeted gene silencing is a quick, cost-effective, and easy-to-perform method to address questions regarding the function of genes, especially when hypomorphic knockdowns are needed. Therefore, effective transfectio... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s13287-019-1144-x

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar
Oxford college:
St Hildas College
Role:
Author
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Publisher:
BMC Publisher's website
Journal:
Stem Cell Research and Therapy Journal website
Volume:
43
Issue:
10
Publication date:
2019-01-24
Acceptance date:
2019-01-10
DOI:
EISSN:
1757-6512
Pubs id:
pubs:966627
URN:
uri:6494deba-b92d-4b64-8c2b-9e62e20d9c03
UUID:
uuid:6494deba-b92d-4b64-8c2b-9e62e20d9c03
Local pid:
pubs:966627

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