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Journal article

R‐loop formation during S phase is restricted by PrimPol‐mediated repriming

Abstract:

During DNA replication, conflicts with ongoing transcription are frequent and require careful management to avoid genetic instability. R‐loops, three‐stranded nucleic acid structures comprising a DNA:RNA hybrid and displaced single‐stranded DNA, are important drivers of damage arising from such conflicts. How R‐loops stall replication and the mechanisms that restrain their formation during S phase are incompletely understood. Here, we show in vivo how R‐loop formation drives a short purine‐ri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.15252/embj.201899793

Authors


Šviković, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Guilliam, TA More by this author
Doherty, AJ More by this author
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
38
Issue:
3
Pages:
Article: e99793
Publication date:
2018-11-26
Acceptance date:
2018-11-06
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:949032
URN:
uri:64949362-2cc6-4672-8d4b-47730633924f
UUID:
uuid:64949362-2cc6-4672-8d4b-47730633924f
Local pid:
pubs:949032

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