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Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.

Abstract:

Transcriptional activation of the human TNF gene involves multiple regulatory elements whose functional properties vary between stimuli and cell types. Here we have used a COS-7 expression system to dissect the transactivating potential of NF-kappa B binding sites in the human TNF promoter region from other regulatory influences. In this model, NF-kappa B acts largely through a dense cluster of three binding sites located 600 nt upstream of the transcription start site. We show that the trans...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.2001.5929

Authors


Udalova, IA More by this author
Kwiatkowski, D More by this author
Journal:
Biochemical and biophysical research communications
Volume:
289
Issue:
1
Pages:
25-33
Publication date:
2001-11-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:649045cc-f2e9-4de6-b7cb-e2a95bae11f7
Source identifiers:
226689
Local pid:
pubs:226689

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