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Naturally mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation

Abstract:

Staphylococcus aureusis a major bacterial pathogen, which causes severe blood and tissue infections that frequently emerge by autoinfection with asymptomatically carried nose and skin populations. However, recent studies report that bloodstream isolates differ systematically from those found in the nose and skin, exhibiting reduced toxicity toward leukocytes. In two patients, an attenuated toxicity bloodstream infection evolved from an asymptomatically carried high-toxicity nasal strain by lo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1520255113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Funding agency for:
Lindemann, C
Grant:
316655
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Funding agency for:
Wyllie, D
Grant:
601783
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Funding agency for:
Wyllie, D
Grant:
601783
More from this funder
Funding agency for:
Wilson, D
Grant:
101237/Z/13/Z
More from this funder
Funding agency for:
Wilson, D
Grant:
101237/Z/13/Z
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
113
Issue:
22
Pages:
E3101–E3110
Publication date:
2016-05-01
Acceptance date:
2016-04-14
DOI:
ISSN:
1091-6490
Source identifiers:
622864
Keywords:
Pubs id:
pubs:622864
UUID:
uuid:6487b6e9-806b-41dd-baf5-089f1fe1dd94
Local pid:
pubs:622864
Deposit date:
2016-05-18

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