Journal article
Naturally mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation
- Abstract:
-
Staphylococcus aureusis a major bacterial pathogen, which causes severe blood and tissue infections that frequently emerge by autoinfection with asymptomatically carried nose and skin populations. However, recent studies report that bloodstream isolates differ systematically from those found in the nose and skin, exhibiting reduced toxicity toward leukocytes. In two patients, an attenuated toxicity bloodstream infection evolved from an asymptomatically carried high-toxicity nasal strain by lo...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 20.5MB, Terms of use)
-
- Publisher copy:
- 10.1073/pnas.1520255113
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Wilson, D
Grant:
101237/Z/13/Z
090532/Z/09/Z
+ National Institute for Health Research
More from this funder
Funding agency for:
Wyllie, D
Rollier-Weissenburger, C
Grant:
601783
+ Seventh Framework Programme
More from this funder
Funding agency for:
Lindemann, C
Wyllie, D
Grant:
316655
601783
Bibliographic Details
- Publisher:
- National Academy of Sciences
- Journal:
- Proceedings of the National Academy of Sciences More from this journal
- Volume:
- 113
- Issue:
- 22
- Pages:
- E3101–E3110
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-04-14
- DOI:
- ISSN:
-
1091-6490
Item Description
- Keywords:
- Pubs id:
-
pubs:622864
- UUID:
-
uuid:6487b6e9-806b-41dd-baf5-089f1fe1dd94
- Local pid:
-
pubs:622864
- Source identifiers:
-
622864
- Deposit date:
-
2016-05-18
Terms of use
- Copyright holder:
- Das et al
- Copyright date:
- 2016
- Notes:
- Freely available online through the PNAS open access option
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record