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Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila.

Abstract:

Essential aspects of innate immune responses to microbial infections appear to be conserved between insects and mammals. In particular, in both groups, transmembrane receptors of the Toll superfamily play a crucial role in activating immune defenses. The Drosophila Toll family member 18-Wheeler had been proposed to sense Gram-negative infection and direct selective expression of peptides active against Gram-negative bacteria. Here we re-examine the role of 18-Wheeler and show that in adults i...

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Publication status:
Published

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Publisher copy:
10.1093/embo-reports/kvf130

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Reichhart, JM More by this author
Journal:
EMBO reports
Volume:
3
Issue:
7
Pages:
666-673
Publication date:
2002-07-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:6482102d-9299-438c-812c-9ac576a8c910
Source identifiers:
99756
Local pid:
pubs:99756

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