Ciliary behaviour and mechano-transduction in the embryonic node: computational testing of hypotheses.
Left-right symmetry breaking in the mammalian embryo is believed to occur in a transient embryonic structure, the node: rotational motion of cilia within this structure creates a leftward flow of liquid that is the first asymmetric event observed. A hypothesis, often referred to as the "two-cilia" hypothesis, proposes that the node contains two kinds of primary cilia: motile cilia, driven by motor proteins, that rotate clockwise generating the leftward flow and passive cilia that act as mecha...Expand abstract
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