Journal article icon

Journal article

Deferoxamine inhibition of malaria is independent of host iron status.

Abstract:

The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei. Peak parasitemia was 32.6% (day 14) in untreated controls and 0.15% (day 7) in rats receiving 0.33 mg/g in 8 hourly DF injections, subcutaneously. DF inhibition of parasite growth was achieved without any reduction in transferrin saturation or hemoglobin synthesis and with only a partial (56%) depletion of hepatic iron stores. Dietary iron depletion resulted i...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.168.1.375

Authors


Hershko, C More by this author
Journal:
The Journal of experimental medicine
Volume:
168
Issue:
1
Pages:
375-387
Publication date:
1988-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:646edbd5-9cb0-467b-9386-e0dc30ce1ff1
Source identifiers:
196459
Local pid:
pubs:196459

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP