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Oxygenases for oxygen sensing

Abstract:

In animals, cellular and physiological responses to oxygen level variations are regulated via the post-translational modification of the heterodimeric hypoxia-inducible transcription factor (HIF). Hydroxylation of the HIF-α subunit at either of two conserved prolyl residues enables binding to the von Hippel-Lindau protein (pVHL) elongin C/B complex (VCB) which targets HIF-α for degradation via the ubiquitin proteasome pathway. Hydroxylation of an asparaginyl residue in the C-terminal transcri...

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Publication status:
Published

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Publisher copy:
10.1351/pac200880081837

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Chowdhury, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Flashman, E More by this author
Volume:
80
Issue:
8
Pages:
1837-1847
Publication date:
2008-08-05
DOI:
EISSN:
1365-3075
ISSN:
0033-4545
URN:
uuid:6469aefc-4800-4ea7-8d50-88fcbe68fa6e
Source identifiers:
40876
Local pid:
pubs:40876

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