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Analysis of rab GTPases.

Abstract:

This unit describes methods to identify proteins interacting with, and regulating, Rab GTPases. Rabs form the largest subgroup of Ras superfamily GTPases, and act as molecular switches controlling the specificity of membrane trafficking. The regulation and the signal readout of Rabs are mediated by four groups of proteins, the GDP-GTP exchange factors (GEFs), GTPase activating proteins (GAPs), Rab chaperones, and effector proteins. Rabs are activated at the membrane surface by specific GEFs t...

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Authors


Langemeyer, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]
Volume:
Chapter 15
Pages:
Unit-15.18
Publication date:
2012-12-05
DOI:
EISSN:
1934-2616
ISSN:
1934-2500
URN:
uuid:6465bb48-7b65-4d0e-a7d9-5e87b8e41151
Source identifiers:
365656
Local pid:
pubs:365656

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