Journal article
Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
- Abstract:
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Background
Expand abstract
Fine definition of targeted CD8+ T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements of HIV-1 T-cell vaccine designs and may predict early vaccine success or failure. Here, lymphocytes from volunteers, who had received candidate HIVconsv vaccines expressing conserved sub-protein regions of HIV-1, were used to define the optimum-length target epitopes and their HLA restriction. In HIV-1-positive patients, CD8+ T-cell respo...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0176418
Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 12
- Issue:
- 4
- Pages:
- e0176418
- Publication date:
- 2017-04-27
- Acceptance date:
- 2017-04-10
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:692254
- UUID:
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uuid:64631c5d-22ec-4ddf-8b3e-6caa3c7a1838
- Local pid:
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pubs:692254
- Source identifiers:
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692254
- Deposit date:
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2017-05-16
Terms of use
- Copyright holder:
- Borthwick et al
- Copyright date:
- 2017
- Notes:
- © 2017 Borthwick et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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