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Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.

Abstract:

Background
Fine definition of targeted CD8+ T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements of HIV-1 T-cell vaccine designs and may predict early vaccine success or failure. Here, lymphocytes from volunteers, who had received candidate HIVconsv vaccines expressing conserved sub-protein regions of HIV-1, were used to define the optimum-length target epitopes and their HLA restriction. In HIV-1-positive patients, CD8+ T-cell respo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0176418

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Akahoshi, T More by this author
Silva-Arrieta, S More by this author
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Grant:
G1001757 and MR/N023668/1
AIDS International Collaborative Project More from this funder
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Grant:
H2020 grant 681137
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
4
Pages:
e0176418
Publication date:
2017-04-27
Acceptance date:
2017-04-10
DOI:
EISSN:
1932-6203
Pubs id:
pubs:692254
URN:
uri:64631c5d-22ec-4ddf-8b3e-6caa3c7a1838
UUID:
uuid:64631c5d-22ec-4ddf-8b3e-6caa3c7a1838
Local pid:
pubs:692254

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