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A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer.

Abstract:

PURPOSE: The primary aim of this study was to measure the objective tumor response rate following treatment with indisulam [E7070; N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide] as second-line therapy in patients with advanced non-small cell lung cancer. The secondary aims were to determine progression-free survival, to assess the safety and tolerability of indisulam, and to study its pharmacokinetic and pharmacodynamic profile. EXPERIMENTAL DESIGN: Patients were randomized to receive indi...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
13
Issue:
6
Pages:
1816-1822
Publication date:
2007-03-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:6461964c-ab8e-4ee4-b4b5-6df208c5e5b8
Source identifiers:
20791
Local pid:
pubs:20791

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