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Layer-by-layer electrostatic entrapment of protein molecules on superparamagnetic nanoparticle: A new strategy to enhance adsorption capacity and maintain biological activity

Abstract:

There is a recent interest to use inorganic-based magnetic nanoparticles as a vehicle to carry biomolecules for various biophysical applications, but direct attachment of the molecules is known to alter their conformation leading to attenuation in activity. In addition, surface immobilization has been limited to monolayer coverage. It is shown that alternate depositions of negatively charged protein molecules, typically bovine serum albumin (BSA) with a positively charged aminocarbohydrate te...

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Publisher copy:
10.1021/jp903100j

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Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Role:
Author
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Journal:
Journal of Physical Chemistry C
Volume:
113
Issue:
34
Pages:
15260-15265
Publication date:
2009-08-27
DOI:
EISSN:
1932-7455
ISSN:
1932-7447
URN:
uuid:6459a048-3684-4acf-8f55-4a3a64f14f9f
Source identifiers:
178833
Local pid:
pubs:178833
Language:
English

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