Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?
The purpose of this article is to set out the hypothesis that arterial PO2 may play a significant role in the regulation of breathing at sea level. The following points are made: 1) Although CO2 is clearly the dominant feedback signal in the acute setting, there is evidence, particularly clinical observation, that the ventilatory response to CO2 may adapt. 2) Although the ventilatory response to an acute variation in alveolar PO2 around sea-level values is feeble, studies at altitude have sho...Expand abstract
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