Journal article
Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci
- Abstract:
-
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureus (MRSA) pandemics, responsible for high rates of mortality worldwide. Nonetheless, little is known regarding the origin and evolution of mecA. Dif...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Funding
+ European Society of Clinical Microbiology and Infectious Diseases
More from this funder
Grant:
Research Grants 2010
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 13
- Issue:
- 4
- Pages:
- e1006674
- Publication date:
- 2017-04-10
- Acceptance date:
- 2017-03-07
- DOI:
- EISSN:
-
1553-7404
- ISSN:
-
1553-7390
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:690927
- UUID:
-
uuid:64250f4d-1f37-43c6-9f0a-6b9687b5e4db
- Local pid:
- pubs:690927
- Source identifiers:
-
690927
- Deposit date:
- 2017-08-11
Terms of use
- Copyright holder:
- Rolo et al
- Copyright date:
- 2017
- Notes:
- © 2017 Rolo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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