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Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.

Abstract:

Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcriptional activation at the upstream promoter reduces transcription from the downstream promoter, as compared with basal transcription conditions (in the absence of an activator). Furth...

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Publisher copy:
10.1093/nar/26.5.1294

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nucleic acids research
Volume:
26
Issue:
5
Pages:
1294-1301
Publication date:
1998-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:641ccd80-9bdc-432d-a5a1-429efa6da9d0
Source identifiers:
30627
Local pid:
pubs:30627

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