- Abstract:
-
Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcriptional activation at the upstream promoter reduces transcription from the downstream promoter, as compared with basal transcription conditions (in the absence of an activator). Furth...
Expand abstract - Publisher copy:
- 10.1093/nar/26.5.1294
-
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- Journal:
- Nucleic acids research
- Volume:
- 26
- Issue:
- 5
- Pages:
- 1294-1301
- Publication date:
- 1998-03-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:641ccd80-9bdc-432d-a5a1-429efa6da9d0
- Source identifiers:
-
30627
- Local pid:
- pubs:30627
- Copyright date:
- 1998
Journal article
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.
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