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Journal article

Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure.

Abstract:

Congestive heart failure (CHF) leads to atrial structural remodelling and increased susceptibility to atrial fibrillation. The underlying molecular mechanisms are poorly understood. We applied high-throughput proteomic and metabolomic analysis to left-atrial cardiomyocytes and tissues obtained from sham and ventricular-tachypaced (VTP, 240 bpm × 24 h and × 2 weeks) CHF dogs. Protein-extracts were subjected to two-dimensional gel electrophoresis using differential in-gel electrophoresis techno...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2010.07.008

Authors


De Souza, AI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Vijayakumar, M More by this author
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Journal:
Journal of molecular and cellular cardiology
Volume:
49
Issue:
5
Pages:
851-863
Publication date:
2010-11-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:6419055e-9c8a-4127-bf0e-ed1513d4fb9c
Source identifiers:
229822
Local pid:
pubs:229822

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