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Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis

Abstract:
Background There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average only, ignoring potential differences among drugs or other aspects of trial findings. Little is known about the impact of a placebo arm on all-cause dropout and dropout due to adverse events. Methods We carried out a systematic r... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/ije/dyy076

Authors


Salanti, G More by this author
Chaimani, A More by this author
Furukawa, TA More by this author
Higgins, JT More by this author
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Publisher:
Oxford University Press Publisher's website
Journal:
International Journal of Epidemiology Journal website
Volume:
47
Issue:
5
Pages:
1454–1464
Publication date:
2018-06-06
Acceptance date:
2018-04-10
DOI:
EISSN:
1464-3685
ISSN:
0300-5771
Pubs id:
pubs:835732
URN:
uri:641240c7-e0c2-4e65-9b74-2bfea602dec8
UUID:
uuid:641240c7-e0c2-4e65-9b74-2bfea602dec8
Local pid:
pubs:835732

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