Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
Background There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average only, ignoring potential differences among drugs or other aspects of trial findings. Little is known about the impact of a placebo arm on all-cause dropout and dropout due to adverse events. Methods We carried out a systematic r... Expand abstract
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