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Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat.

Abstract:

Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) of untreated patients implanted with stimulation electrodes for the treatment of Parkinson's disease (PD) demonstrate strong coherence with the cortical electroencephalogram over the beta-frequency range (15-30 Hz). However, studies in animal models of PD emphasize increased temporal coupling in cortico-basal ganglia circuits at substantially lower frequencies, undermining the potential usefulness of these models. Here ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
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Journal:
The European journal of neuroscience
Volume:
21
Issue:
5
Pages:
1413-1422
Publication date:
2005-03-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:640091b6-e7c1-477a-9267-f47210238a17
Source identifiers:
71043
Local pid:
pubs:71043

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