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A post hoc analysis of osmotherapy use in the erythropoietin in traumatic brain injury study-associations with acute kidney injury and mortality

Abstract:

OBJECTIVES: Mannitol and hypertonic saline are used to treat raised intracerebral pressure in patients with traumatic brain injury, but their possible effects on kidney function and mortality are unknown.

DESIGN: A post hoc analysis of the erythropoietin trial in traumatic brain injury (ClinicalTrials.gov NCT00987454) including daily data on mannitol and hypertonic saline use.

SETTING: Twenty-nine university-affiliated teac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/ccm.0000000000004853

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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Critical Care Medicine Journal website
Volume:
49
Issue:
4
Pages:
e394-e403
Publication date:
2021-01-22
DOI:
EISSN:
1530-0293
ISSN:
0090-3493
Pmid:
33566466

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