Thesis
Dissecting domain-specific functions of the IGF2/M6P receptor
- Abstract:
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The P-type lectin Mannose 6-phosphate/Insulin-like growth factor 2 receptor (M6P/IGF2R) is a type I trans-membrane protein with 15 homologous extracellular domains that bind several ligands. While domains 3, 5 and 9 bind to Mannose 6-Phosphate (M6P), domain 11 binds to IGF2 (Insulin-like growth factor 2). In mice, igf2r expression is monoallelic and full knock-out of the receptor maternal allele (Igf2r-m/+p) results in developmental abnormalities and neonatal lethality...
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Funding
Cancer Research UK
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- UUID:
-
uuid:63ee7b6a-a619-4d42-973e-e888dc427378
- Deposit date:
- 2018-07-13
Terms of use
- Copyright holder:
- Can, S
- Copyright date:
- 2016
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