Journal article
Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
- Abstract:
-
Conjugates of cell-penetrating peptides (CPP) and splice redirecting oligonucleotides (ON) display clinical potential as attested by in vivo experimentation in murine models of Duchenne muscular dystrophy. However, micromolar concentrations of these conjugates are required to obtain biologically relevant responses as a consequence of extensive endosomal sequestration following endocytosis. Recent work from our group has demonstrated that appending stearic acid to CPPs increases their efficien...
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- Publisher copy:
- 10.1016/j.jconrel.2011.04.013
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Bibliographic Details
- Journal:
- Journal of controlled release : official journal of the Controlled Release Society
- Volume:
- 153
- Issue:
- 2
- Pages:
- 163-172
- Publication date:
- 2011-07-01
- DOI:
- EISSN:
-
1873-4995
- ISSN:
-
0168-3659
- Source identifiers:
-
271654
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:271654
- UUID:
-
uuid:63eacc96-602b-4740-9fb2-93979e4a885b
- Local pid:
- pubs:271654
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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