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Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

Abstract:

Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00116-10

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Journal:
Journal of virology
Volume:
84
Issue:
16
Pages:
8202-8208
Publication date:
2010-08-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
58630

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