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Peptidomimetic‐based identification of FDA approved compounds inhibiting IRE1 activity

Abstract:

Inositol-requiring enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is a major mediator of the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Tumour cells experience ER stress due to adverse environmental cues such as hypoxia or nutrient shortage and high metabolic/protein-folding demand. To cope with those stresses, cancer cells utilise IRE1 signalling as an adaptive mechanism. Here, we report the discovery of the FDA-approved com...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/febs.15372

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Division:
MSD
Department:
Surgical Sciences
Role:
Author
Publisher:
Wiley
Journal:
FEBS Journal More from this journal
Article number:
15372
Publication date:
2020-05-23
Acceptance date:
2020-05-19
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
Language:
English
Keywords:
Pubs id:
1110349
Local pid:
pubs:1110349
Deposit date:
2020-06-12

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