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On the antibiotic activity of oxazolomycin.

Abstract:

Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy-2,2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N-H and O-H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X-ray analysis. A direct synthesis of this unit has been established via the opening of beta-lactones by a range of amines, and their antibacterial activit...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2008.05.105

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
18
Issue:
14
Pages:
4081-4086
Publication date:
2008-07-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:34277
UUID:
uuid:63e1452e-ed9d-450c-9c87-472312c9a411
Local pid:
pubs:34277
Source identifiers:
34277
Deposit date:
2012-12-19

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