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Journal article

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.

Abstract:

Analysis of diverse eukaryotes has revealed that recombination events cluster in discrete genomic locations known as hotspots. In humans, a zinc-finger protein, PRDM9, is believed to initiate recombination in >40% of hotspots by binding to a specific DNA sequence motif. However, the PRDM9 coding sequence is disrupted in the dog genome assembly, raising questions regarding the nature and control of recombination in dogs. By analyzing the sequences of PRDM9 orthologs in a number of dog breed...

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Publisher copy:
10.1101/gr.124123.111

Authors


Axelsson, E More by this author
Webster, MT More by this author
Ratnakumar, A More by this author
Ponting, CP More by this author
Lindblad-Toh, K More by this author
Journal:
Genome research
Volume:
22
Issue:
1
Pages:
51-63
Publication date:
2012-01-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:63dfd503-dad6-487b-9d64-0f2189948c4e
Source identifiers:
246669
Local pid:
pubs:246669

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