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High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19

Abstract:

Objective: To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis.

Design: Case-control study.

Setting: Academic research.

Patient(s): Cases = 3,223 women with surgically confirmed endometriosis; controls = 1,190 women without endometriosis and 7,060 population samples.

Intervention(s): Analysis of 11,98...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
More by this author
Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Genetic and Genomic Epidemiology Unit
Role:
Author
More by this author
Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
More by this author
Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author

Contributors

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Name:
Wellcome Trust
Funding agency for:
Zondervan, K
Morris, A
Grant:
WT085235/Z/08/Z
WT081682/Z/06/Z
More from this funder
Name:
"National Health and Medical Research Council (NHMRC) of Australia", "Australian Research Council"
Funding agency for:
Nyholt, D
More from this funder
Name:
"Department of Health"
Funding agency for:
Kennedy, S
More from this funder
Name:
National Health and Medical Research Council (NHMRC) of Australia
Funding agency for:
Montgomery, G
More from this funder
Name:
Australian Research Council (ARC)
Publisher:
Elsevier
Journal:
Fertility and Sterility More from this journal
Volume:
95
Issue:
7
Pages:
2236-2240
Publication date:
2011-06-01
DOI:
ISSN:
0015-0282
Language:
English
Keywords:
Subjects:
UUID:
uuid:63df75f2-12f9-4177-a8e0-34489ef18cf2
Local pid:
ora:5813
Deposit date:
2011-10-25

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