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High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19

Abstract:

Objective: To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis.

Design: Case-control study.

Setting: Academic research.

Patient(s): Cases = 3,223 women with surgically confirmed endometriosis; controls = 1,190 women without endometriosis and 7,060 population samples.

Intervention(s): Analysis of 11,98...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
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Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Genetic and Genomic Epidemiology Unit
Role:
Author
More by this author
Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
More by this author
Institution:
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Role:
Author
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Contributors

Role:
Funder
Wellcome Trust More from this funder
National Health and Medical Research Council (NHMRC) of Australia More from this funder
National Institutes of Health (NIH, US) More from this funder
Endometriosis Associations of Queensland and Western Australia More from this funder
Cerylid Biosciences (Melbourne) More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Fertility and Sterility Journal website
Volume:
95
Issue:
7
Pages:
2236-2240
Publication date:
2011-06-01
DOI:
ISSN:
0015-0282
Language:
English
Keywords:
Subjects:
UUID:
uuid:63df75f2-12f9-4177-a8e0-34489ef18cf2
Local pid:
ora:5813
Deposit date:
2011-10-25

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