Journal article icon

Journal article

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

Abstract:

Background: A limited number of studies have assessed the risk of common diseases when combining information from several predisposing polymorphisms. In most cases, individual polymorphisms only moderately increase risk (~20%), and they are thought to be unhelpful in assessing individuals' risk clinically. This is often because, for any given disease, very few common risk alleles have been confirmed. Methods and findings: Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allel...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.0030374

Authors


More by this author
Institution:
"Peninsula Medical School, Exeter, UK"
Department:
Department of Diabetes Research and Vascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Diabetes Research Labs
Role:
Author
More by this author
Institution:
"Bart's and the London Queen Mary's School of Medicine and Dentistry, University of London, London, UK"
Department:
Centre of Diabetes and Metabolic Medicine
Role:
Author
More by this author
Institution:
"School of Medicine, Newcastle-upon-Tyne, UK"
Department:
Department of Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Weedon, M
More from this funder
Funding agency for:
Hattersley, A
Diabetes UK More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
3
Issue:
10
Article number:
e374
Publication date:
2006-10-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Language:
English
Keywords:
Subjects:
UUID:
uuid:63dcddf9-a9b3-45aa-a5b4-0a2d5dcd133e
Local pid:
ora:2517
Deposit date:
2009-01-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP