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IncX2 and IncX1-X2 Hybrid Plasmids Coexisting in a FosA6-Producing Escherichia coli Strain

Abstract:

IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1 Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.00536-17

Authors


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Role:
Author
ORCID:
0000-0003-2490-1201
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-4508-7969
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Name:
NIAID NIH HHS
Grant:
R21 AI123747
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
61
Issue:
7
Article number:
e00536-17
Publication date:
2017-06-27
Acceptance date:
2017-04-19
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
28438937
Language:
English
Keywords:
Pubs id:
pubs:691432
UUID:
uuid:63daaaeb-552b-4a64-9e2b-210dab168743
Local pid:
pubs:691432
Source identifiers:
691432
Deposit date:
2019-03-04

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