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Modulation of the voltage-dependent K+ current by intracellular Mg2+ in rat aortic smooth muscle cells.

Abstract:

OBJECTIVE: Intracellular magnesium ions (Mg2+i) are important in the regulation of a wide range of cellular metabolic processes and modulation of a variety of ion channels. Mg2+ deficiency has been implicated in the aetiology of various cardiovascular diseases. However, potential targets and mechanisms of action of Mg2+i in the cardiovascular system remain poorly understood. We therefore investigated the effect of Mg2+i on the voltage-gated K+ (KV) channels in rat aortic myocytes (RAMs). MET...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Crowley, BL More by this author
Smirnov, SV More by this author
Journal:
Cardiovascular research
Volume:
65
Issue:
2
Pages:
387-396
Publication date:
2005-02-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:63d6bb38-1631-4ee5-a949-957e4b439787
Source identifiers:
386839
Local pid:
pubs:386839

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