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Association of the aromatase gene with Alzheimer's disease in women.

Abstract:

Associations have been reported of aromatase polymorphisms with Alzheimer's disease (AD). We studied nine polymorphisms in 207 cases of AD, 23 cases of mild cognitive impairment (MCI) and 233 controls, all from the OPTIMA cohort. We replicated two reported associations and found others. Our findings were consistent between AD and MCI. Further, our results were sex-specific, i.e. there were significant interactions between certain polymorphisms and gender, and the associations with AD were alm...

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Publication status:
Published

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Authors


Butler, HT More by this author
Warden, DR More by this author
Hogervorst, E More by this author
Ragoussis, J More by this author
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Journal:
Neuroscience letters
Volume:
468
Issue:
3
Pages:
202-206
Publication date:
2010-01-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:63c4cc96-9e8f-46ce-85b6-7005f98e304e
Source identifiers:
71841
Local pid:
pubs:71841

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