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Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression

Abstract:

The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-11 and domains-3-5-9, respectively. Mammalian maternal Igf2r allele expression exceeds the paternal allele due to imprinting (silencing). Igf2r null-allele maternal transmission results in placenta and heart over-growth and perinatal lethality (>...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
9
Article number:
11388
Publication date:
2019-08-06
Acceptance date:
2019-07-19
DOI:
EISSN:
2045-2322
Pubs id:
pubs:1035101
UUID:
uuid:63c29aed-f64e-4f52-86c0-fc4fd230c39e
Local pid:
pubs:1035101
Source identifiers:
1035101
Deposit date:
2019-07-25

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