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The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria

Abstract:

A retrospective study of 261 Vietnamese adults with severe malaria was conducted to determine the relationship between cerebrospinal fluid (CSF) levels of metabolites of the kynurenine pathway, the incidence of neurologic complications, and the disease outcome. Three metabolites were measured: the excitotoxin quinolinic acid (QA); the protective receptor antagonist kynurenic acid (KA); and the proinflammatory mediator picolinic acid (PA). These measurements were related prospectively to CSF l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Medical Sciences Division - Nuffield Department of Clinical Laboratory Sciences
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Institution:
"Centre for Tropical Diseases, Ho Chi Minh City, Vietnam"
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Oxford-Wellcome Centre for Tropical and Infectious Diseases,John Radcliffe Hospital
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Institution:
"Centre for Tropical Diseases, Ho Chi Minh City, Vietnam"
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Institution:
"Centre for Tropical Diseases, Ho Chi Minh City, Vietnam"
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Grant:
044055/Z/95/Z/140
Publisher:
University of Chicago Press Publisher's website
Journal:
The Journal of Infectious Diseases Journal website
Volume:
185
Issue:
5
Pages:
650-656
Publication date:
2002-03-05
ISSN:
0022-1899
URN:
uuid:63bd1d93-827b-4043-b214-0a3f6c98b4cc
Local pid:
ora:1440

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