Journal article icon

Journal article

Activity Parameters of Subthalamic Nucleus Neurons Selectively Predict Motor Symptom Severity in Parkinson's Disease

Abstract:

Parkinson's disease (PD) is a heterogeneous disorder that leads to variable expression of several different motor symptoms. While changes in firing rate, pattern, and oscillation of basal ganglia neurons have been observed in PD patients and experimental animals, there is limited evidence linking them to specific motor symptoms. Here we examined this relationship using extracellular recordings of subthalamic nucleus neurons from 19 PD patients undergoing surgery for deep brain stimulation. Fo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1523/JNEUROSCI.1803-13.2014

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Oxford college:
Exeter College
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0003-0538-5109
More from this funder
Name:
Medical Research Council
Grant:
U138197109
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
34
Issue:
18
Pages:
6273-6285
Publication date:
2014-04-30
Acceptance date:
2014-03-10
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
24790198
Language:
English
Keywords:
Pubs id:
pubs:552804
UUID:
uuid:63bcdcc8-eb80-4fd2-83af-768b8e31cede
Local pid:
pubs:552804
Source identifiers:
552804
Deposit date:
2019-06-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP