Journal article icon

Journal article

Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient

Abstract:

We report here the sequence and functional characterization of a recombinantly expressed autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the VHCDR2. The recombinant mAb 131 is specific for the γ-subunit of the fetal AChR to which it bound with sub-nanomolar apparent affinity...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Role:
Author
ORCID:
0000-0001-5737-7325
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Austrian Science Fund
Funding agency for:
Cetin, H
Grant:
Erwin Schrödinger Fellowship (J3589
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
1
Article number:
14426
Publication date:
2017-10-31
Acceptance date:
2017-10-10
DOI:
ISSN:
2045-2322
Pmid:
29089519
Language:
English
Pubs id:
pubs:742282
UUID:
uuid:63b7c57a-e4f4-42d5-8aba-092747704358
Local pid:
pubs:742282
Source identifiers:
742282
Deposit date:
2018-01-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP