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Journal article

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

Abstract:

Shelterin component TRF2 prevents ATM activation, while POT1 represses ATR signalling at telomeres. Here, we investigate the mechanism of G2/M arrest triggered by telomeres uncapped through TRF2 or POT1 inhibition in human cells. We find that telomere damage-activated ATR and ATM phosphorylate p53, as well as CHK1 and CHK2, thus activating two independent pathways to prevent progression into mitosis with uncapped telomeres. Surprisingly, telomere damage targets the CDC25C phosphatase for prot...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2012.191

Authors


Thanasoula, M More by this author
Escandell, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Journal:
EMBO Journal
Volume:
31
Issue:
16
Pages:
3398-3410
Publication date:
2012-08-15
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:63b2c3e8-ef33-4be1-a007-7e5f924aad16
Source identifiers:
351000
Local pid:
pubs:351000

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