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The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

Abstract:

Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We revi...

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Publisher copy:
10.1016/j.ddstr.2012.02.002
Journal:
Drug Discovery Today: Therapeutic Strategies More from this journal
Volume:
9
Issue:
2-3
Pages:
e91-e100
Publication date:
2012-09-01
DOI:
EISSN:
1740-6773
ISSN:
1740-6773
Language:
English
Pubs id:
pubs:371410
UUID:
uuid:63abf861-b82d-499c-8211-8c26b037c234
Local pid:
pubs:371410
Source identifiers:
371410
Deposit date:
2013-11-17

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