Journal article

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

Abstract:: Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition. © 2012 Elsevier Ltd. All rights reserved.

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APA Style

Thalhammer, A., Aik, W., Bagg, E., & Schofield, C. (2012). The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets. Drug Discovery Today: Therapeutic Strategies, 9(2-3), e91–e100.

MLA Style

Thalhammer, A., et al. “The Potential of 2-Oxoglutarate Oxygenases Acting on Nucleic Acids as Therapeutic Targets.” Drug Discovery Today: Therapeutic Strategies, vol. 9, no. 2-3, 2012, pp. e91–e100.

Chicago Style

Thalhammer, A, W Aik, E Bagg, and C Schofield. 2012. “The Potential of 2-Oxoglutarate Oxygenases Acting on Nucleic Acids as Therapeutic Targets.” Drug Discovery Today: Therapeutic Strategies 9 (2-3): e91–e100.
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Publisher copy:: 10.1016/j.ddstr.2012.02.002

Authors

+ Thalhammer, A More by this author

Role:: Author

+ Aik, W More by this author

Role:: Author

+ Bagg, E More by this author

Role:: Author

+ Schofield, C More by this author

Role:: Author

Journal:: Drug Discovery Today: Therapeutic Strategies More from this journal
Volume:: 9
Issue:: 2-3
Pages:: e91-e100
Publication date:: 2012-09-01
DOI:: 10.1016/j.ddstr.2012.02.002
EISSN:: 1740-6773
ISSN:: 1740-6773

Language:: English
Pubs id:: pubs:371410
UUID:: uuid:63abf861-b82d-499c-8211-8c26b037c234
Local pid:: pubs:371410
Source identifiers:: 371410
Deposit date:: 2013-11-17

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Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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