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Thesis

Real-time studies of DNA repair kinetics following low-LET short-pulse electron radiation

Abstract:

Radiation-induced damage to the genomic DNA of cells may lead to errors in transcription and replication and, if not repaired correctly, these may result in mutations, genomic instability and cell death. Laser microbeams have generally been used by many research groups to investigate the real-time dynamics of protein recruitment in response to DNA insults in mammalian cells; however, such irradiations induce a plethora of DNA damage (including UV base damage, base damage, SSBs and DSBs and...

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Institution:
University of Oxford
Oxford college:
Jesus College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Carlos Daniel Mendes de Oliveira Martins
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:63a874a6-9348-4504-b4cd-b1cfd129b75d
Local pid:
ora:11728

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