Thesis
Real-time studies of DNA repair kinetics following low-LET short-pulse electron radiation
- Abstract:
-
Radiation-induced damage to the genomic DNA of cells may lead to errors in transcription and replication and, if not repaired correctly, these may result in mutations, genomic instability and cell death. Laser microbeams have generally been used by many research groups to investigate the real-time dynamics of protein recruitment in response to DNA insults in mammalian cells; however, such irradiations induce a plethora of DNA damage (including UV base damage, base damage, SSBs and DSBs and...
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Authors
Contributors
+ O'Neill, P
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
+ Vojnovic, B
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
+ Cancer Research UK; Medical Research Council
More from this funder
Funding agency for:
Mendes de Oliveira Martins, C
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:63a874a6-9348-4504-b4cd-b1cfd129b75d
- Local pid:
- ora:11728
- Deposit date:
- 2015-06-24
Terms of use
- Copyright holder:
- Mendes de Oliveira Martins, C
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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