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Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma.

Abstract:

The cause of the unique elevation in fasting plasma levels of the orexigenic gastric hormone ghrelin in many patients with Prader-Willi syndrome (PWS) is unclear. We measured fasting and postprandial plasma ghrelin in nonobese (n = 16 fasting and n = 8 postprandial) and obese non-PWS adults (n = 16 and 9), adults with genetically confirmed PWS (n = 26 and 10), and patients with hypothalamic obesity from craniopharyngioma tumors (n = 9 and 6). We show that 1) plasma ghrelin levels decline norm...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2003-032209

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
90
Issue:
5
Pages:
2681-2690
Publication date:
2005-05-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:63a4f87b-a478-4395-9b45-011e109bdabf
Source identifiers:
138443
Local pid:
pubs:138443

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