Thymic dendritic cells: phenotype and function.

Journal article

Interdigitating (IDC) cells of the thymus have been characterized in situ by their ultrastructure and phenotype. Thymic dendritic cells (DC), thought to represent their in vitro correlate, resemble splenic DC in their ability to initiate peripheral T cell responses. In vivo, however, DC of the thymus have been implicated in tolerance induction, although at one time they were thought to impart MHC-restriction on developing T cells. Our present understanding of these areas is reviewed here. An ...

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Authors: Fairchild, P; Austyn, J

• Journal: International reviews of immunology
• Volume: 6
• Issue: 2-3
• Pages: 187-196
• Publication date: 1990-01-01
• DOI: 10.3109/08830189009056629
• EISSN: 1563-5244
• ISSN: 0883-0185
• Language: English
• Keywords: Lymphocyte Activation; Immunophenotyping; Dendritic Cells; Cell Movement; Cell Differentiation; Antigens; T-Lymphocytes; Mammals; Histocompatibility Antigens Class II; Transplantation, Heterotopic; Animals; Birds; Spleen; Biological Markers; Thymus Gland; Histocompatibility Antigens Class I