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Journal article

Simulated ablation for detection of cells impacting paracrine signalling in histology analysis

Abstract:

Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later come in form of both direct physical interactions, as well as inputs from gradients of secreted signalli...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1093/imammb/dqx022

Authors


Taylor-King, JP More by this author
Baratchart, E More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Publisher:
Oxford University Press Publisher's website
Journal:
Mathematical Medicine and Biology Journal website
Volume:
36
Issue:
1
Pages:
93–112
Publication date:
2018-02-14
Acceptance date:
2017-12-21
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
Pubs id:
pubs:820630
URN:
uri:639cc7fd-cc9d-469a-8e79-e64ba7a0934d
UUID:
uuid:639cc7fd-cc9d-469a-8e79-e64ba7a0934d
Local pid:
pubs:820630

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