Simulated ablation for detection of cells impacting paracrine signalling in histology analysis
Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later come in form of both direct physical interactions, as well as inputs from gradients of secreted signalli...Expand abstract
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Copyright © 2018 The Authors. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications.
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